Read the paper in Cell Systems
Cite as: De Kegel et al. (2021) Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines. Cell Systems
SHAP profiles for paralog synthetic lethality predictions
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SHAP (SHapley Additive exPlanations) values are numeric measures of feature credit; they indicate how much each feature pushes a specific prediction higher or lower. Where features are correlated, credit will be distributed among them rather than assigned to a single feature. SHAP profiles show the relationship between feature credit and the feature's value (z-score). Below is an example SHAP profile for the paralog pair AKT1/AKT2.