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Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines
Data
(current)
SHAP profiles
Read the paper on
bioRxiv
Cite as: De Kegel et al. (2020)
Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines.
bioRxiv
Supplemental Files
Table S1 - Validated SL paralog pairs
Table S2 - Gene dependency scores computed by CERES
Table S3 - Matrix of gene loss per cell line
Table S4 - Results of testing paralog pairs (A1, A2) for association between A1 dependency and A2 gene loss
Table S5 - Final training dataset of SL and non-SL paralog pairs
Table S6 - Descriptions and predictive power of 22 features of paralog pairs
Table S7 - Performance of our classifier compared to three other SL classifiers
Table S8 - Feature values and predictions for ~36.6k paralog pairs
Table S9 - SHAP values associated with all features for all predictions
Table S10 -
ASF1A/ASF1B
and
COPS7A/COPS7B
viability data