Welcome to CancerGD.org, which integrates results from loss-of-function screens in cell line panels with mutational profiles to identify genetic dependencies associated with specific driver gene mutations. These dependencies include oncogene addictions - e.g. cell lines with ERBB2 amplification have an increased sensitivity to ERBB2 inhibition - and non-oncogene addictions or synthetic lethalities - e.g. cell lines with SMAD4 loss display an increased sensitivity to inhibition of multiple mitotic kinases. This resource currently includes dependencies identified using RNA interference approaches (siRNA and shRNA) and CRISPR based screens. It contains results from 7 studies, and will be expanded as more results become available.
The manuscript describing CancerGD.org is available here.
Predictions for synthetic lethal paralogs are available here.
We welcome your comments and queries.
Enter your search criteria below. In the 'Driver gene' search box, typing two letters of a gene name will display a menu of matching gene names. The 'Tissue' and 'Study' menu options will be updated depending on gene selected.)