Details of driver genes investigated

Driver geneEntrez IDFull nameSynonymsAlterations ConsideredStudiesTissuesTargets
ACVR2A 92 activin A receptor type 2A ACVR2 | ACTRII Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 2 676
AFDN 4301 afadin, adherens junction formation factor AF-6 | MLLT4 | AF6 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 396
AFF4 27125 AF4/FMR2 family member 4 MCEF | AF5Q31 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 268
APC 324 APC, WNT signaling pathway regulator DP3 | DP2.5 | PPP1R46 | DP2 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 2 905
ARID1A 8289 AT-rich interaction domain 1A BAF250a | P270 | SMARCF1 | C1orf4 | B120 | C10rf4 | BAF250 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 4 5 2336
ARID1B 57492 AT-rich interaction domain 1B KIAA1235 | BAF250b | p250R | ELD/OSA1 | DAN15 | 6A3-5 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 2 273
ASXL1 171023 additional sex combs like 1, transcriptional regulator KIAA0978 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 2 1648
B2M 567 beta-2-microglobulin Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 294
BCOR 54880 BCL6 corepressor KIAA1575 | FLJ20285 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 2 389
BRAF 673 B-Raf proto-oncogene, serine/threonine kinase BRAF1 Recurrent mutations 1 2 562
BRCA1 672 BRCA1, DNA repair associated BRCC1 | RNF53 | FANCS | PPP1R53 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 798
BRCA2 675 BRCA2, DNA repair associated FANCD1 | FANCD | FAD | FAD1 | FACD | BRCC2 | XRCC11 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 3 1685
CCND1 595 cyclin D1 D11S287E | U21B31 | BCL1 | PRAD1 Amplifications or recurrent mutations 3 3 1264
CCNE1 898 cyclin E1 CCNE Amplifications or recurrent mutations 1 1 930
CDH1 999 cadherin 1 UVO | CD324 | uvomorulin Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 2 1761
CDKN2A 1029 cyclin dependent kinase inhibitor 2A INK4a | p19 | MTS1 | p16 | CDK4I | p14 | INK4 | MLM | p19Arf | p16INK4a | p14ARF | CDKN2 | ARF | CMM2 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 5 8 4074
CDKN2C 1031 cyclin dependent kinase inhibitor 2C INK4C | p18 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 3 1148
CTNNB1 1499 catenin beta 1 armadillo | CTNNB | beta-catenin Amplifications or recurrent mutations 1 2 455
EGFR 1956 epidermal growth factor receptor ERBB1 | ERBB Amplifications or recurrent mutations 2 2 460
EP300 2033 E1A binding protein p300 KAT3B | p300 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 3 1698
ERBB2 2064 erb-b2 receptor tyrosine kinase 2 HER-2 | HER2 | NEU | CD340 | NGL Amplifications 4 3 2523
EZH2 2146 enhancer of zeste 2 polycomb repressive complex 2 subunit ENX-1 | EZH1 | KMT6 | KMT6A Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 587
FANCA 2175 Fanconi anemia complementation group A FACA | FAA | FA-H | FAH | FANCH Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 2 707
FBXW7 55294 F-box and WD repeat domain containing 7 FBW7 | FBX30 | CDC4 | SEL-10 | AGO | SEL10 | FBXW6 | FLJ11071 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 2 440
GNAS 2778 GNAS complex locus GNAS1 | NESP | NESP55 | SCG6 | GPSA | SgVI | GNASXL Amplifications or recurrent mutations 2 3 1434
HEY1 23462 hes related family bHLH transcription factor with YRPW motif 1 HESR1 | HESR-1 | bHLHb31 | CHF-2 | HRT-1 | HERP2 | CHF2 Amplifications or recurrent mutations 1 1 643
KDM6A 7403 lysine demethylase 6A UTX Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 3 743
KRAS 3845 KRAS proto-oncogene, GTPase KRAS1 | KRAS2 Recurrent mutations 3 4 2205
MAP2K4 6416 mitogen-activated protein kinase kinase 4 SERK1 | JNKK1 | MKK4 | MEK4 | PRKMK4 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 2 1048
MDM2 4193 MDM2 proto-oncogene HDM2 | MGC5370 Amplifications or recurrent mutations 1 1 224
MSH2 4436 mutS homolog 2 HNPCC | HNPCC1 | COCA1 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 172
MSH6 2956 mutS homolog 6 GTBP Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 2 651
MYC 4609 MYC proto-oncogene, bHLH transcription factor MYCC | bHLHe39 | c-Myc Amplifications 3 5 1782
NCOA3 8202 nuclear receptor coactivator 3 RAC3 | TRAM-1 | SRC-3 | bHLHe42 | SRC3 | AIB1 | ACTR | TNRC16 | KAT13B | p/CIP | CAGH16 Amplifications or recurrent mutations 1 1 931
NCOR1 9611 nuclear receptor corepressor 1 TRAC1 | hN-CoR | hCIT529I10 | KIAA1047 | N-CoR | MGC104216 | PPP1R109 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 2 540
NF1 4763 neurofibromin 1 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 4 1271
NRAS 4893 NRAS proto-oncogene, GTPase N-ras Recurrent mutations 2 2 1232
PIK3CA 5290 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PI3K Amplifications or recurrent mutations 4 5 2800
PIK3R1 5295 phosphoinositide-3-kinase regulatory subunit 1 p85-ALPHA | GRB1 | p85 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 2 372
PPM1D 8493 protein phosphatase, Mg2+/Mn2+ dependent 1D Wip1 | PP2C-DELTA Amplifications or recurrent mutations 3 1 1156
PTCH1 5727 patched 1 NBCCS | PTCH | BCNS Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 197
PTEN 5728 phosphatase and tensin homolog MHAM | MMAC1 | BZS | TEP1 | PTEN1 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 4 4 2176
PTPRK 5796 protein tyrosine phosphatase, receptor type K R-PTP-kappa Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 1 289
RB1 5925 RB transcriptional corepressor 1 RB | PPP1R130 | OSRC Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 3 1602
RNF43 54894 ring finger protein 43 URCC | FLJ20315 | DKFZp781H0392 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 3 1787
RPL22 6146 ribosomal protein L22 L22 | EAP Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 2 836
SKP2 6502 S-phase kinase associated protein 2 FBL1 | p45 | FBXL1 Amplifications or recurrent mutations 1 1 1095
SMAD4 4089 SMAD family member 4 DPC4 | MADH4 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 3 4 1863
SMARCA4 6597 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 FLJ39786 | SNF2 | SWI2 | BRG1 | hSNF2b | SNF2LB | SNF2L4 | BAF190 | SNF2-BETA Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 2 437
SPOP 8405 speckle type BTB/POZ protein BTBD32 | TEF2 Amplifications or recurrent mutations 1 1 738
STK11 6794 serine/threonine kinase 11 PJS | LKB1 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 2 2 341
TP53 7157 tumor protein p53 LFS1 | p53 Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 5 9 3690
UBR5 51366 ubiquitin protein ligase E3 component n-recognin 5 KIAA0896 | EDD | DD5 | EDD1 | HYD Homozygous deletions, nonsense mutations, frameshift mutations, splice-site mutations and recurrent mutations 1 2 677